STUDY: A Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells

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A Comprehensive Review of the Therapeutic Value of Urine-Derived Stem Cells
Qian Zhou1†
, Yiyu Cheng1†
, Fang Sun1†
, Jie Shen1
, M. I. Nasser 2
, Ping Zhu2
, Xueyan Zhang1
,Yuxiang Li 3
, Guangming Yin3
*, Yuequn Wang4
*, Xiushan Wu2,4
* and Mingyi Zhao1,2
*

1
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China, 2
Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China, 3
Department of Urology, The Third Xiangya Hospital, Central South University, Changsha, China, 4

The Center for Heart Development, State Key Laboratory of Development Biology of Freshwater Fish, Key Laboratory of MOE for Development Biology and Protein Chemistry, College of Life Sciences, Hunan Normal University, Changsha, China

Stem cells possess regenerative powers and multidirectional differentiation potential and
play an important role in disease treatment and basic medical research. Urine-derived stem
cells (USCs) represent a newly discovered type of stem cell with biological characteristics
similar to those of mesenchymal stromal cells (MSCs), including their doubling time and
immunophenotype. USCs are noninvasive and can be readily obtained from voided urine
and steadily cultured. Based on advances in this field, USCs and their secretions have
increasingly emerged as ideal sources. USCs may play regulatory roles in the cellular
immune system, oxidative stress, revascularization, apoptosis and autophagy. This review
summarizes the applications of USCs in tissue regeneration and various disease
treatments. Furthermore, by analysing their limitations, we anticipate the development
of more feasible therapeutic strategies to promote USC-based individualized treatment....

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